Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway | Zendy

Zhenyang Zhang | Zendy; Wen-Wei Lin | Zendy; Lei Gao | Zendy; Keqing Chen | Zendy; Chuangcai Yang | Zendy; Linwei Zhuang | Zendy; Shuai Peng | Zendy; Mingqiang Kang | Zendy; Jiangbo Lin | Zendy

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Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway

Author(s) -

Zhenyang Zhang,

Wen-Wei Lin,

Lei Gao,

Keqing Chen,

Chuangcai Yang,

Linwei Zhuang,

Shuai Peng,

Mingqiang Kang,

Jiangbo Lin

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20182377

Subject(s) - apoptosis , oncogene , cell growth , microrna , immunoprecipitation , cell culture , biology , microbiology and biotechnology , cancer research , rna splicing , function (biology) , rna , reporter gene , cell , chemistry , gene , gene expression , biochemistry , genetics , cell cycle

Circular RNAs (circRNAs) formed by back-splicing play multiple roles in the occurrence and development of cancer. Here, we found that hsa_circ_0004370 was up-regulated in both esophageal cancer (EC) tissues and cell lines. Loss function of hsa_circ_0004370 by si-RNA significantly suppressed proliferation and invasion and promoted apoptosis in both EC cell lines. The sponging of miR-1294 by hsa_circ_0004370 was bioinformatically predicted and subsequently verified by luciferase reporter assay and RNA immunoprecipitation assay. Further, hsa_circ_0004370 involved in the up-regulation of LASP1 by sponging miR-1294. Besides, the inhibition of the down-regulated hsa_circ_0004370 on cell malignant behaviors was rescued by miR-1294 inhibitor. Finally, this rescue effect was abrogated by suppressing the expression of LASP1. The results present here suggest that hsa_circ_0004370 functions as an oncogene on cell proliferation, apoptosis, and invasion via miR-1294/LASP1 axis.

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