FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways | Zendy

Nanwen Zhang | Zendy; Zhiwei Liu | Zendy; Hongbin Luo | Zendy; Weifang Wu | Zendy; Kaimei Nie | Zendy; Lin Cai | Zendy; Shuangyu Tan | Zendy; Xiaole Chen | Zendy; Ying Huang | Zendy; Jiaxing Liu | Zendy; Meina Lv | Zendy; Xin Zhang | Zendy; Yun Fan | Zendy; Yu-Ying Lin | Zendy; Shennan Ye | Zendy; Yang Liu | Zendy; Lixian Wu | Zendy; Jianhua Xu | Zendy

Open Access

FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

Author(s) -

Nanwen Zhang,

Zhiwei Liu,

Hongbin Luo,

Weifang Wu,

Kaimei Nie,

Lin Cai,

Shuangyu Tan,

Xiaole Chen,

Ying Huang,

Jiaxing Liu,

Meina Lv,

Xin Zhang,

Yun Fan,

Yu-Ying Lin,

Shennan Ye,

Yang Liu,

Lixian Wu,

Jianhua Xu

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20182263

Subject(s) - arthritis , medicine , synovial fluid , tumor necrosis factor alpha , rheumatoid arthritis , curcumin , inflammation , pharmacology , pathogenesis , mapk/erk pathway , interleukin , chemistry , immunology , endocrinology , cytokine , osteoarthritis , kinase , pathology , biochemistry , alternative medicine

Rheumatoid arthritis (RA) is a chronic articular synovial inflammatory disease. The precise etiology underlying the pathogenesis of RA remains unknown. We aimed to investigate the inhibitory effect of curcumin analog FM0807 (curcumin salicylate monoester, 2-hydroxy-, 4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-methoxyphenyl ester) on experimental RA and investigate its possible mechanisms of action.

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