Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China | Zendy

Yongtao Wang | Zendy; Buamina Maitusong | Zendy; Yi-Tong Ma | Zendy; Zhen-Yan Fu | Zendy; Yi-Ning Yang | Zendy; Xiang Ma | Zendy; XiaoMei Li | Zendy; Fen Liu | Zendy; BangDang Chen | Zendy

Open Access

Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China

Author(s) -

Yongtao Wang,

Buamina Maitusong,

Yi-Tong Ma,

Zhen-Yan Fu,

Yi-Ning Yang,

Xiang Ma,

XiaoMei Li,

Fen Liu,

BangDang Chen

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20182129

Subject(s) - acyltransferases , coronary artery disease , polymorphism (computer science) , cholesterol , gene , genetics , gene polymorphism , population , biology , triglyceride , china , medicine , genotype , biosynthesis , environmental health , geography , archaeology

Acyl-CoA: cholesterol acyltransferases (ACAT) is the only enzyme that catalyzes the synthesis of cholesterol esters (CE) from free cholesterol and long-chain fatty acyl-CoA and plays a critical role in cellular cholesterol homeostasis. In the present study, our primary objective was to explore whether the single-nucleotide polymorphisms (SNPs) in ACAT-2 gene were associated with coronary artery disease (CAD) in Uygur subjects, in Xinjiang, China.

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