OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study | Zendy

Houlai Shang | Zendy; Yuedong Hao | Zendy; Wenhao Hu | Zendy; Xiaohui Hu | Zendy; Qing Jin | Zendy

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OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study

Author(s) -

Houlai Shang,

Yuedong Hao,

Wenhao Hu,

Xiaohui Hu,

Qing Jin

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20182023

Subject(s) - osteoarthritis , genotyping , genotype , osteopontin , allele , locus (genetics) , body mass index , case control study , medicine , genetics , polymorphism (computer science) , restriction fragment length polymorphism , gene , bioinformatics , biology , pathology , alternative medicine

Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) < 25 kg/m 2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.

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