Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture | Zendy

Yan Yang | Zendy; Xiyang Wang | Zendy; Zheng Liu | Zendy; Xiao Xiao | Zendy; Wenkai Hu | Zendy; Zhicheng Sun | Zendy

Open Access

Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture

Author(s) -

Yan Yang,

Xiyang Wang,

Zheng Liu,

Xiao Xiao,

Wenkai Hu,

Zhicheng Sun

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20181708

Subject(s) - pi3k/akt/mtor pathway , apoptosis , protein kinase b , microbiology and biotechnology , ly294002 , chemistry , signal transduction , caspase 3 , cell growth , programmed cell death , biology , biochemistry

Previous studies have indicated that osteogenic protein-1 has protective effects on the biological functions of intervertebral disc cells. Hyperosmolarity is an important physicochemical factor within the disc nucleus pulposus (NP) region, which obviously promotes NP cell apoptosis.

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