Long non-coding RNA SPRY4-IT1 promotes epithelial–mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis | Zendy

Mingjun Fan | Zendy; Yonghui Zou | Zendy; Pengjuan He | Zendy; Shuai Zhang | Zendy; Xiaomei Sun | Zendy; Chang-Zhong Li | Zendy

Open Access

Long non-coding RNA SPRY4-IT1 promotes epithelial–mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis

Author(s) -

Mingjun Fan,

Yonghui Zou,

Pengjuan He,

Shuai Zhang,

Xiaomei Sun,

Chang-Zhong Li

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20181339

Subject(s) - competing endogenous rna , vimentin , gene knockdown , epithelial–mesenchymal transition , biology , malat1 , microrna , long non coding rna , blot , cancer research , in vivo , microbiology and biotechnology , rna , cell culture , downregulation and upregulation , gene , genetics , immunology , immunohistochemistry

Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4 intronic transcript 1 ( SPRY4-IT1 ) predicates poor prognosis and promotes tumor progress in cervical cancer (CC). However, the underlying mechanism of SPRY4-IT1 in CC remains unknown. The aim of the present study is to evaluate the function and mechanism of SPRY4-IT1 in CC.

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