
PRISMA-compliant meta-analysis: association of metabolic syndrome and its components with the risk of chronic obstructive pulmonary disease
Author(s) -
Linyang Ye,
Xi Huang,
Qingxiang Wang,
Hualing Yang,
Dongmiao Cai,
Zhanxiang Wang
Publication year - 2018
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20181199
Subject(s) - pulmonary disease , meta analysis , metabolic syndrome , medicine , disease , bioinformatics , computational biology , biology , obesity
A preferred reporting items for systematic reviews and meta-analyses-compliant meta-analysis was conducted to test the association of metabolic syndrome and its components with the risk of chronic obstructive pulmonary disease (COPD) based on observational studies. Literature retrieval, article selection and data extraction were done by two researchers independently. Total 16 articles (20 independent studies) were analyzed with 3915 COPD patients and 25,790 control participants. Overall analysis indicated that metabolic syndrome was significantly associated with 1.53-fold (95% confidence interval [CI]: 1.23-1.9, P <0.001) increased risk of COPD, with moderate heterogeneity ( I 2 = 74.3%). Of four metabolic components, hypertension was significantly associated with 1.55-fold (95% CI: 1.14-2.11, P =0.005) increased risk, and averaged levels of systolic blood pressure (weighted mean difference [WMD] = 3.626 mmHg, 95% CI: 1.537-5.714, P <0.001) and glucose (WMD = 2.976 mmol/l, 95% CI: 0.141-5.812; P =0.04) were significantly higher in COPD patients than in control participants, yet that of body mass index (WMD = -1.463 kg/m 2 , 95% CI: -2.716 to -0.211, P =0.022) were significantly lower. Gender, race, source of control participants, matched status and sample size were identified as accountable factors for significant heterogeneity. Altogether, the presence of metabolic syndrome, especially its component hypertension, was associated with significantly increased risk of COPD.
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