A trial sequential meta-analysis of TNF-α –308G&gt;A (rs800629) gene polymorphism and susceptibility to colorectal cancer | Zendy

Raju K. Mandal | Zendy; Munawwar Ali Khan | Zendy; Arif Hussain | Zendy; Naseem Akhter | Zendy; Arshad Jawed | Zendy; Sajad Ahmad Dar | Zendy; Mohd Wahid | Zendy; Aditya K. Panda | Zendy; Mohtashim Lohani | Zendy; Bhartendu Nath Mishra | Zendy; Shafiul Haque | Zendy

Open Access

A trial sequential meta-analysis of TNF-α –308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer

Author(s) -

Raju K. Mandal,

Munawwar Ali Khan,

Arif Hussain,

Naseem Akhter,

Arshad Jawed,

Sajad Ahmad Dar,

Mohd Wahid,

Aditya K. Panda,

Mohtashim Lohani,

Bhartendu Nath Mishra,

Shafiul Haque

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20181052

Subject(s) - odds ratio , single nucleotide polymorphism , meta analysis , colorectal cancer , snp , medicine , confidence interval , subgroup analysis , genotype , allele , genetic model , oncology , tumor necrosis factor alpha , gastroenterology , gene , genetics , biology , cancer

Tumor necrosis factor-α (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of TNF -α - 308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between TNF -α - 308 G>A gene polymorphism with CRC risk.

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