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In the present study, we aimed at determining the potential role of rs12917 polymorphism of the O -6-methylguanine-DNA methyltransferase ( MGMT ) gene in the occurrence of cancer. Based on the available data from the online database, we performed an updated meta-analysis. We retrieved 537 articles from our database research and finally selected a total of 54 case-control studies (21010 cases and 34018 controls) for a series of pooling analyses. We observed an enhanced risk in cancer cases compared with controls, using the genetic models T/T compared with C/C ( P -value of association test &lt;0.001; odds ratio (OR) = 1.29) and T/T compared with C/C+C/T ( P &lt;0.001; OR = 1.32). We detected similar positive results in the subgroups 'Caucasian', and 'glioma' (all P &lt;0.05; OR &gt; 1). However, we detected negative results in our analyses of most of the other subgroups ( P &gt;0.05). Begg's and Egger's tests indicated that the results were free of potential publication bias, and sensitivity analysis suggested the stability of the pooling results. In summary, the T/T genotype of MGMT rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.

The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls