LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in papillary thyroid carcinoma | Zendy

Yanyan Shen | Zendy; Erjie Xia | Zendy; Adheesh Bhandari | Zendy; Xiaohui Wang | Zendy; Guilong Guo | Zendy

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LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in papillary thyroid carcinoma

Author(s) -

Yanyan Shen,

Erjie Xia,

Adheesh Bhandari,

Xiaohui Wang,

Guilong Guo

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20180862

Subject(s) - thyroid carcinoma , cancer research , carcinogenesis , gene knockdown , thyroid cancer , gene silencing , long non coding rna , cell growth , thyroid , biology , cancer , epithelial–mesenchymal transition , rna , gene , metastasis , endocrinology , genetics

Evidence has been provided that long noncoding RNAs (LncRNAs) play major roles in affecting essential physiological processes, and many of which seem to have functional roles in tumorigenesis and progression. However, the intrinsic molecular mechanism of LncRNAs acting on papillary thyroid carcinoma is not well understood. In the present study, we found that PROX1-AS1 levels were obviously increased in thyroid cancer cells compared with the normal thyroid epithelial cells. Knockdown of PROX1-AS1 gene expression by siRNA could inhibit cell proliferation. Subsequently, we also observed that silencing PROX1-AS1 might inhibit invasion and migration of thyroid cancer cell lines via modulating the expression of epithelial-mesenchymal transition related proteins. In conclusion, our study indicated that LncRNA PROX1-AS1 could promote papillary thyroid carcinoma development and might serve as a potential targeting marker for papillary thyroid carcinoma.

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