The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis | Zendy

Qianyun Feng | Zendy; Sheng Zheng | Zendy; Jia Zheng | Zendy

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The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

Author(s) -

Qianyun Feng,

Sheng Zheng,

Jia Zheng

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20180453

Subject(s) - osteoporosis , microrna , epigenetics , bone remodeling , bioinformatics , disease , non coding rna , biology , computational biology , medicine , gene , genetics , pathology , endocrinology

Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be the underlying mechanisms that link genetic and environmental factors with increased risks of osteoporosis and bone fracture. MicroRNA (miRNA), a major category of small noncoding RNA with 20-22 bases in length, is recognized as one important epigenetic modification. It can mediate post-transcriptional regulation of target genes with cell differentiation and apoptosis. In this review, we aimed to profile the role of miRNA in bone remodeling and its therapeutic implications for osteoporosis. A deeper insight into the role of miRNA in bone remodeling and osteoporosis can provide unique opportunities to develop a novel diagnostic and therapeutic approach of osteoporosis.

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