Antisense oligonucleotides targeting angiotensinogen: insights from animal studies | Zendy

Chia-Hua Wu | Zendy; Ya Wang | Zendy; Murong Ma | Zendy; Adam E. Mullick | Zendy; Rosanne M. Crooke | Zendy; Mark J. Graham | Zendy; Alan Daugherty | Zendy; Hong Lü | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

Author(s) -

Chia-Hua Wu,

Ya Wang,

Murong Ma,

Adam E. Mullick,

Rosanne M. Crooke,

Mark J. Graham,

Alan Daugherty,

Hong Lü

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20180201

Subject(s) - oligonucleotide , renin–angiotensin system , computational biology , biology , scope (computer science) , bioinformatics , medicine , genetics , endocrinology , computer science , dna , blood pressure , programming language

Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research