Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture | Zendy

Zhiwen Zhang | Zendy; Feng Wen | Zendy; Chengjian He | Zendy; Jun Yu | Zendy

Open Access

Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture

Author(s) -

Zhiwen Zhang,

Feng Wen,

Chengjian He,

Jun Yu

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20171703

Subject(s) - resveratrol , apoptosis , tunel assay , terminal deoxynucleotidyl transferase , microbiology and biotechnology , organ culture , chemistry , cell culture , programmed cell death , caspase 3 , cell , biology , biochemistry , in vitro , genetics

Nucleus pulposus (NP) cell apoptosis is a typical feature within the degenerative disc. High magnitude compression significantly promotes NP cell apoptosis. Several studies have indicated that resveratrol has protective effects on disc cell's normal biology.

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