Interferon regulatory factor 1 inactivation in human cancer | Zendy

Khaldoon Alsamman | Zendy; Omar S. El-Masry | Zendy

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Interferon regulatory factor 1 inactivation in human cancer

Author(s) -

Khaldoon Alsamman,

Omar S. El-Masry

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20171672

Subject(s) - interferon regulatory factors , irf1 , cancer , biology , interferon , immunotherapy , cancer immunotherapy , immunology , cancer research , genetics , immune system , transcription factor , innate immune system , gene

Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.

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