The roles of interleukins in perfusion recovery after peripheral arterial disease | Zendy

Lingdan Chen | Zendy; Hanwei Liu | Zendy; Mingjie Yuan | Zendy; Wenju Lu | Zendy; Jian Wang | Zendy; Tao Wang | Zendy

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The roles of interleukins in perfusion recovery after peripheral arterial disease

Author(s) -

Lingdan Chen,

Hanwei Liu,

Mingjie Yuan,

Wenju Lu,

Jian Wang,

Tao Wang

Publication year - 2018

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20171455

Subject(s) - arteriogenesis , neovascularization , perfusion , medicine , peripheral , angiogenesis , inflammation , ischemia , blood flow , blood supply , arterial disease , cardiology , vascular disease , surgery

In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the leg makes blood flow dependent on the capacity of neovascularization. There is no current medication that is able to increase neovascularization to the ischemic limb and directly treat the primary problem of PAD. An increasing body of evidence supports the notion that inflammation plays an important role in the vascular remodeling and perfusion recovery after PAD. Interleukins (ILs), a group of proteins produced during inflammation, have been considered to be important for angiogenesis and arteriogenesis after tissue ischemia. This review summarizes the latest clinical and experimental developments of the role of ILs in blood perfusion recovery after PAD.

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