Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway | Zendy

Wenping Wang | Zendy; Pei Li | Zendy; Jiagang Xu | Zendy; Xiangkun Wu | Zendy; Zhiliang Guo | Zendy; Lijing Fan | Zendy; Ruipeng Song | Zendy; Jianli Wang | Zendy; Wei Li | Zendy; Haijun Teng | Zendy

Open Access

Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

Author(s) -

Wenping Wang,

Pei Li,

Jiagang Xu,

Xiangkun Wu,

Zhiliang Guo,

Lijing Fan,

Ruipeng Song,

Jianli Wang,

Wei Li,

Haijun Teng

Publication year - 2017

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20171454

Subject(s) - resveratrol , pi3k/akt/mtor pathway , apoptosis , protein kinase b , microbiology and biotechnology , senescence , chemistry , nucleus , cell , signal transduction , cancer research , biology , biochemistry

Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within the degenerative disc. Resveratrol is a newly identified phytoalexin that has protective effects on cartilaginous tissue.

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