Thymic stromal lymphopoietin-induced HOTAIR activation promotes endothelial cell proliferation and migration in atherosclerosis | Zendy

Yudong Peng | Zendy; Kai Meng | Zendy; Lili Jiang | Zendy; Yucheng Zhong | Zendy; Yong Yang | Zendy; Yin Lan | Zendy; Qiutang Zeng | Zendy; Longxian Cheng | Zendy

Open Access

Thymic stromal lymphopoietin-induced HOTAIR activation promotes endothelial cell proliferation and migration in atherosclerosis

Author(s) -

Yudong Peng,

Kai Meng,

Lili Jiang,

Yucheng Zhong,

Yong Yang,

Yin Lan,

Qiutang Zeng,

Longxian Cheng

Publication year - 2017

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20170351

Subject(s) - hotair , thymic stromal lymphopoietin , cancer research , long non coding rna , pi3k/akt/mtor pathway , cell growth , protein kinase b , signal transduction , transactivation , microbiology and biotechnology , biology , chemistry , immunology , transcription factor , downregulation and upregulation , inflammation , biochemistry , gene

Endothelial cells' (EC) injury is a major step for the pathological progression of atherosclerosis. Recent study demonstrated that thymic stromal lymphopoietin (TSLP) exerts a protective role in atherosclerosis. However, the effect of TSLP and the exact molecular mechanism involved in EC remains unknown. In the present study, we found that long noncoding RNA (lncRNA) HOTAIR was much lower in EC from atherosclerotic plaque. Functional assays showed that HOTAIR facilitated cell proliferation and migration, and suppressed apoptosis in EC. Moreover, we demonstrated that TSLP functions upstream of HOTAIR. We found that serum level of TSLP was decreased in atherosclerosis patients and serum TSLP level positively correlated with HOTAIR expression in EC. Further investigation demonstrated that TSLP activated HOTAIR transcription through PI3K/AKT-IRF1 pathway and then regulates the EC proliferation and migration. TSLP-HOTAIR axis also plays a protective role in low-density lipoprotein (ox-LDL)-induced EC injury. Taken together, TSLP-HOTAIR may be a potential therapy for EC dysfunction in atherosclerosis.

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