The relationship between systemic iron homeostasis and erythropoiesis | Zendy

Gautam Rishi | Zendy; V. Nathan Subramaniam | Zendy

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The relationship between systemic iron homeostasis and erythropoiesis

Author(s) -

Gautam Rishi,

V. Nathan Subramaniam

Publication year - 2017

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20170195

Subject(s) - hepcidin , erythropoiesis , transferrin receptor , transferrin , iron homeostasis , hormone , homeostasis , ineffective erythropoiesis , receptor , biology , microbiology and biotechnology , endocrinology , immunology , medicine , anemia , biochemistry , inflammation , metabolism

Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis.

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