Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- κB signalling pathway | Zendy

C. West | Zendy; Michael McDermott | Zendy

Open Access

Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- κB signalling pathway

Author(s) -

C. West,

Michael McDermott

Publication year - 2017

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20170180

Subject(s) - microrna , translation (biology) , signalling , apoptosis , psychological repression , nf κb , biology , microbiology and biotechnology , messenger rna , disease , function (biology) , signalling pathways , cancer research , signal transduction , bioinformatics , medicine , gene expression , genetics , gene

MicroRNAs are important cellular mediators of mRNA degradation and translation repression, which in turn can have an impact on various processes and, if their function is perturbed, can cause disease. Here, we summarize the recent manuscript by Zhong et al. [(2017) Biosci. Rep. 37 , BSR20160578], which explores microRNA-146a and how it may play an indirect yet vital role in the proliferation of osteoarthritis (OA) chondrocytes. The data presented by the authors could have important implications for future OA therapies.

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