Rab23’s genetic structure, function and related diseases: a review | Zendy

Liqiang Zheng | Zendy; Sumin Chi | Zendy; Chengxin Li | Zendy

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Rab23’s genetic structure, function and related diseases: a review

Author(s) -

Liqiang Zheng,

Sumin Chi,

Chengxin Li

Publication year - 2017

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20160410

Subject(s) - biology , autophagy , microbiology and biotechnology , hedgehog signaling pathway , mutation , signal transduction , neural tube , bioinformatics , genetics , gene , embryo , apoptosis

Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab23 is also a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab23 has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visceral, and cutaneous tumor. In addition, Rab23 may play joint roles in autophagosome formation during anti-infection process against Group A streptococcus. In this review, we give a brief review on the functions of Rab23, summarize the involvement of Rab23 in genetic research, membrane trafficking, and potential autophagy pathway, especially focus on tumor promotion, disease pathogenesis, and discuss the possible underlying mechanisms that are regulated by Rab23.

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