Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma | Zendy

Si Liu | Zendy; Yiyang Li | Zendy; Hongmei Xu | Zendy; Kaichen Wang | Zendy; Nan Li | Zendy; Jia Li | Zendy; Tao Sun | Zendy; Ying Xu | Zendy

Open Access

Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma

Author(s) -

Si Liu,

Yiyang Li,

Hongmei Xu,

Kaichen Wang,

Nan Li,

Jia Li,

Tao Sun,

Ying Xu

Publication year - 2016

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20160122

Subject(s) - methyltransferase , histone methyltransferase , epigenetics , renal cell carcinoma , histone , methylation , biology , dna methylation , translation (biology) , cancer research , carcinoma , computational biology , gene expression , microbiology and biotechnology , genetics , medicine , messenger rna , gene

In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that confers genomic stability. There was enhanced expression of SET domain-containing histone methyltransferases in whole lysates of all classes of renal carcinoma. In metastatic high grade clear cell carcinoma, this expression was more pronounced. Though we could not demonstrate direct correlation, we showed that epigenetic modification by methylation is associated with decreased genomic translation of Rad51.

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