MicroRNA 486-3P as a stability marker in acute coronary syndrome | Zendy

Tianling Wei | Zendy; Lasse Folkersen | Zendy; Ewa Ehrenborg | Zendy; Anders Gabrielsen | Zendy

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MicroRNA 486-3P as a stability marker in acute coronary syndrome

Author(s) -

Tianling Wei,

Lasse Folkersen,

Ewa Ehrenborg,

Anders Gabrielsen

Publication year - 2016

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20160023

Subject(s) - acute coronary syndrome , microrna , medicine , computational biology , cardiology , biology , genetics , myocardial infarction , gene

Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).

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