Open AccessBiochemical and structural characterization of DNA ligases from bacteria and archaea
Author(s) -
Giulia Pergolizzi,
Gerd K. Wagner,
Richard P. Bowater
Publication year - 2016
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20160003
Subject(s) - biochemistry , biology , dna , nicotinamide adenine dinucleotide , nad+ kinase , enzyme , dna ligases , dna ligase , dna repair
DNA ligases seal breaks in DNA using a co-factor that supplies adenylate for the reaction. We review biochemical and structural characterization of DNA ligases from bacteria and archaea, highlighting novel co-factor variants that act as inhibitors and/or non-natural substrates of the enzymes.
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