Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation | Zendy

Shu Yang | Zendy; Bo Wu | Zendy; Haimei Sun | Zendy; Fengqing Ji | Zendy; Tingyi Sun | Zendy; Yan Zhao | Zendy; Deshan Zhou | Zendy

Open Access

Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation

Author(s) -

Shu Yang,

Bo Wu,

Haimei Sun,

Fengqing Ji,

Tingyi Sun,

Yan Zhao,

Deshan Zhou

Publication year - 2015

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150290

Subject(s) - colorectal cancer , methylation , cancer research , cell growth , dna methylation , biology , cancer , chemistry , genetics , gene , gene expression

E2F1 promoted miR-34c transcription which reduced its target stem cell factor (SCF) and inhibited colorectal cancer (CRC) cell proliferation. While, SCF increased E2F1 production, suggesting an existence of E2F1-miR-34c-SCF negative feedback loop, which was interrupted by hyper-methylation of miR-34c promoter in CRC cells.

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