The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression | Zendy

Nelson Ho | Zendy; Jodi Morrison | Zendy; Andreza Silva | Zendy; Brenda L. Coomber | Zendy

Open Access

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

Author(s) -

Nelson Ho,

Jodi Morrison,

Andreza Silva,

Brenda L. Coomber

Publication year - 2016

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150267

Subject(s) - glycolysis , cancer cell , hexokinase , oxygen tension , cancer research , biology , colorectal cancer , apoptosis , protein kinase b , cell culture , cancer , microbiology and biotechnology , tumor microenvironment , chemistry , phosphorylation , enzyme , biochemistry , oxygen , tumor cells , genetics , organic chemistry

Colorectal cancer cells respond to 3BP via phosphorylation of AKT at residue Thr-308. The availability of glucose in culturing media plays a crucial role in 3BP sensitivity, although independently of HKII expression.

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