Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair | Zendy

Edward L. Bolt | Zendy; Tabitha Jenkins | Zendy; Valeria Moreira Russo | Zendy; Sharlene Ahmed | Zendy; James R. Cavey | Zendy; Simon Cass | Zendy

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Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair

Author(s) -

Edward L. Bolt,

Tabitha Jenkins,

Valeria Moreira Russo,

Sharlene Ahmed,

James R. Cavey,

Simon Cass

Publication year - 2015

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150249

Subject(s) - escherichia coli , mitomycin c , dna , identification (biology) , microbiology and biotechnology , biology , genetics , computational biology , gene , botany

A genome-wide protein expression screen in Escherichia coli has identified new mitomycin C resistance factors, genes ygaQ and rpmG . These were characterized, revealing that ygaQ encodes a new nuclease enzyme and that RpmG is likely be an “idiosyncratic ribosomal protein” with a role in DNA repair by MutM.

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