Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death | Zendy

Katja Hrovat Arnež | Zendy; Michaela Kindlova | Zendy; Nilesh J. Bokil | Zendy; James M. Murphy | Zendy; Matthew J. Sweet | Zendy; Gregor Gunčar | Zendy

Open Access

Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death

Author(s) -

Katja Hrovat Arnež,

Michaela Kindlova,

Nilesh J. Bokil,

James M. Murphy,

Matthew J. Sweet,

Gregor Gunčar

Publication year - 2015

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150246

Subject(s) - necroptosis , gene isoform , programmed cell death , biology , hek 293 cells , microbiology and biotechnology , ectopic expression , cell culture , effector , apoptosis , biochemistry , gene , genetics

We show that mixed lineage kinase domain-like (MLKL) isoform 2, which lacks the pseudokinase domain and activation loop phosphorylation sites, is a more potent activator of cell death compared with MLKL isoform 1. Both MLKL isoforms are expressed in human monocyte-derived macrophages.

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