Oriented cell division: new roles in guiding skin wound repair and regeneration | Zendy

Shaowei Yang | Zendy; Kui Ma | Zendy; Zhijun Geng | Zendy; Xiaoyan Sun | Zendy; Xiaobing Fu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Oriented cell division: new roles in guiding skin wound repair and regeneration

Author(s) -

Shaowei Yang,

Kui Ma,

Zhijun Geng,

Xiaoyan Sun,

Xiaobing Fu

Publication year - 2015

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150225

Subject(s) - cell division , microbiology and biotechnology , asymmetric cell division , cell polarity , regeneration (biology) , biology , mitosis , division (mathematics) , polarity (international relations) , morphogenesis , cell , cell fate determination , genetics , gene , transcription factor , arithmetic , mathematics

Tissue morphogenesis depends on precise regulation and timely co-ordination of cell division and also on the control of the direction of cell division. Establishment of polarity division axis, correct alignment of the mitotic spindle, segregation of fate determinants equally or unequally between daughter cells, are essential for the realization of oriented cell division. Furthermore, oriented cell division is regulated by intrinsic cues, extrinsic cues and other cues, such as cell geometry and polarity. However, dysregulation of cell division orientation could lead to abnormal tissue development and function. In the present study, we review recent studies on the molecular mechanism of cell division orientation and explain their new roles in skin repair and regeneration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research