Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors | Zendy

Akira Inokawa | Zendy; Tatsutoshi Inuzuka | Zendy; Terunao Takahara | Zendy; Hideki Shibata | Zendy; Masatoshi Maki | Zendy

Open Access

Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors

Author(s) -

Akira Inokawa,

Tatsutoshi Inuzuka,

Terunao Takahara,

Hideki Shibata,

Masatoshi Maki

Publication year - 2015

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20150215

Subject(s) - adipogenesis , biology , transcription factor , microbiology and biotechnology , 3t3 l1 , cellular differentiation , ccaat enhancer binding proteins , nuclear protein , biochemistry , gene , mesenchymal stem cell

Decrease in intracellular amount of phospholipid scramblase 3 (PLSCR3) is accompanied by enhanced unconventional secretion during differentiation of mouse preadipocytic 3T3-L1 cells. Forced overexpression of PLSCR3 in 3T3-L1 cells inhibited adipogenesis by suppressing induction of late stage pro-adipogenic transcription factors.

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