Open AccessBiochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis
Author(s) -
Laura E. Batten,
Alice E. Parnell,
Neil J. Wells,
Amber L. Murch,
Petra C. F. Oyston,
Peter L. Roach
Publication year - 2015
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20150203
Subject(s) - polyphosphate , francisella tularensis , biochemistry , biology , virulence , kinase , intracellular , francisella , gene , phosphate
The polyphosphate kinase 2 (PPK2) from the intracellular pathogen Francisella tularensis has been characterized by a range of biochemical methods and X-ray crystallography. The antibiotic sensitivity of a deletion mutant lacking the gene encoding PPK2 is also reported.
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