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RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of Gαo Sabine TRAVER*, Carole BIDOT*, Nathalie SPASSKY†, Tania BALTAUSS*, Marie-France DE TAND*, Jean-Le! on THOMAS†, Bernard ZALC†, Isabelle JANOUEIX-LEROSEY* and Jean DE GUNZBURG* *INSERM U-528, Institut Curie – Recherche, 26 rue d’Ulm, 75248 Paris Cedex 05, France, and †INSERM U-495, Ho# pital de la Salpe# trie' re, 75651 Paris Cedex 13, France