Cap-binding complex (CBC) | Zendy

Thomas Gonatopoulos-Pournatzis | Zendy; Victoria H. Cowling | Zendy

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Cap-binding complex (CBC)

Author(s) -

Thomas Gonatopoulos-Pournatzis,

Victoria H. Cowling

Publication year - 2013

Publication title -

biochemical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.706

H-Index - 265

eISSN - 1470-8728

pISSN - 0264-6021

DOI - 10.1042/bj20131214

Subject(s) - rna splicing , gene , gene expression , biology , transcription (linguistics) , regulation of gene expression , messenger rna , microbiology and biotechnology , translation (biology) , alternative splicing , genetics , computational biology , rna , linguistics , philosophy

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.

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