Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells | Zendy

Hayley Dingsdale | Zendy; Emmanuel Sunday Okeke | Zendy; Muhammad Awais | Zendy; Lee P. Haynes | Zendy; David N. Criddle | Zendy; Robert Sutton | Zendy; Alexei V. Tepikin | Zendy

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Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells

Author(s) -

Hayley Dingsdale,

Emmanuel Sunday Okeke,

Muhammad Awais,

Lee P. Haynes,

David N. Criddle,

Robert Sutton,

Alexei V. Tepikin

Publication year - 2013

Publication title -

biochemical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.706

H-Index - 265

eISSN - 1470-8728

pISSN - 0264-6021

DOI - 10.1042/bj20121864

Subject(s) - dissolution , biophysics , microbiology and biotechnology , chemistry , cancer cell , cancer , materials science , biology , genetics

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junctions accompanied the tail withdrawal.

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