The mitochondrial citrate carrier: a new player in inflammation | Zendy

Vittoria Infantino | Zendy; Paolo Convertini | Zendy; Liana Cucci | Zendy; Maria Antonietta Panaro | Zendy; Maria Antonietta Di Noia | Zendy; Rosa Calvello | Zendy; Ferdinando Palmieri | Zendy; Vito Iacobazzi | Zendy

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The mitochondrial citrate carrier: a new player in inflammation

Author(s) -

Vittoria Infantino,

Paolo Convertini,

Liana Cucci,

Maria Antonietta Panaro,

Maria Antonietta Di Noia,

Rosa Calvello,

Ferdinando Palmieri,

Vito Iacobazzi

Publication year - 2011

Publication title -

biochemical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.706

H-Index - 265

eISSN - 1470-8728

pISSN - 0264-6021

DOI - 10.1042/bj20111275

Subject(s) - cytosol , inflammation , mitochondrion , gene silencing , efflux , reactive oxygen species , microbiology and biotechnology , lipopolysaccharide , mitochondrial matrix , chemistry , biochemistry , gene , biology , enzyme , immunology

The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

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