Design and delivery of messenger RNA-based vaccines | Zendy

Chantal Pichon | Zendy; Federico Perche | Zendy

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Design and delivery of messenger RNA-based vaccines

Author(s) -

Chantal Pichon,

Federico Perche

Publication year - 2021

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio_2021_151

Subject(s) - messenger rna , immune system , biology , acquired immune system , dna vaccination , rna , innate immune system , immunology , antigen , immunity , virology , computational biology , immunization , gene , genetics

In these last years, we are witnessing the emergence of a new class of biopharmaceuticals based on messenger RNA (mRNA). One of the most promising applications of mRNA is its use as vaccines. Many reports, including ours, have demonstrated the preclinical efficacy of mRNA vaccines. mRNA vaccines have several advantages over traditional vaccines or even DNA vaccines. Unlike attenuated or inactivated vaccines, mRNA encodes for a specific antigen that will be expressed in situ and stimulates both the innate immune system and an adaptive immunity to promote both humoral and cellular immune responses.

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