DNA in a twist? How topoisomerases solve topological problems in DNA | Zendy

Natassja G. Bush | Zendy; Monica Agarwal | Zendy; Sara R. Henderson | Zendy; Nidda F. Waraich | Zendy; Anthony Maxwell | Zendy

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DNA in a twist? How topoisomerases solve topological problems in DNA

Author(s) -

Natassja G. Bush,

Monica Agarwal,

Sara R. Henderson,

Nidda F. Waraich,

Anthony Maxwell

Publication year - 2018

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio04002026

Subject(s) - topoisomerase , dna , dna supercoil , circular bacterial chromosome , twist , biology , computational biology , genetics , topology (electrical circuits) , chemistry , microbiology and biotechnology , dna replication , mathematics , geometry , combinatorics

DNA topoisomerases have been described as ‘the magicians of the DNA world’, somehow allowing DNA strands to pass through each other. These ingenious enzymes are both essential and potentially dangerous, as any interruption in their DNA breakage-reunion reactions can lead to chromosome breaks and cell death. This has led to their development as important targets for antibacterial and anti-cancer chemotherapy.

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