Expanding the RNA alphabet: The expanding world of mRNA modifications | Zendy

Benjamin Delatte | Zendy; François Fuks | Zendy

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Expanding the RNA alphabet: The expanding world of mRNA modifications

Author(s) -

Benjamin Delatte,

François Fuks

Publication year - 2016

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio03802013

Subject(s) - pseudouridine , n6 methyladenosine , rna , chromatin , biology , epigenetics , gene , computational biology , genetics , 5 hydroxymethylcytosine , dna , genome , messenger rna , 5 methylcytosine , gene expression , microbiology and biotechnology , dna methylation , transfer rna , methyltransferase , methylation

Our understanding of the post-transcriptional modifications that decorate mRNAs, a regulatory layer positioned between DNA and proteins, is in its infancy. Recent advances in genome-wide mapping of pseudouridine (), N6-methyladenosine (m6A), 5-methylcytosine (5mrC), its oxidation product 5-hydroxymethylcytosine (5hmrC), and N1-methyladenosine (m1A) have proven that these modifications unsuspectedly occur from dozens to thousands of different gene transcripts in eukaryotic cells. Therefore epigenetics cannot only be restricted to chromatin modifications, and, when studying gene regulation, one has to consider the expanding kingdom of RNA modifications, also known as the epitranscriptome.

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