Unravelling why some people have drug side effects

Pharmaceuticals have had an immense positive impact on modern medicine. However, they often trigger unintended and injurious side effects, or adverse drug reactions (ADRs). Traditionally, many ADRs were thought to be rare and difficult to predict. However, recent advances in both experimental and computational biology are revolutionizing how we understand both individual patient physiology and pharmaceutical compounds, providing an opportunity to unravel the mysteries of why drug side effects occur and why some people have drug side effects and others do not.