Discovery, metabolism and functions of NAD and NADP
Author(s) -
Magali R. VanLinden,
Renate Hvidsten Skoge,
Mathias Ziegler
Publication year - 2015
Publication title -
the biochemist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 7
eISSN - 1740-1194
pISSN - 0954-982X
DOI - 10.1042/bio03701009
Subject(s) - nad+ kinase , nicotinamide adenine dinucleotide , nicotinamide , nicotinamide adenine dinucleotide phosphate , redox , chemistry , biochemistry , moiety , metabolism , niacinamide , cofactor , stereochemistry , enzyme , oxidase test , organic chemistry
Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are two major players in metabolism as they participate as electron carriers in a multitude of redox reactions. Moreover, they act in life and death decisions on a cellular level in all known life forms. NAD and NADP both exist in two states; the oxidized forms are characterized by a positive charge on the nicotinamide (Nam) moiety, denoted NAD+ and NADP+ respectively. The reduced forms are denoted NADH and NADPH (Figure 1).
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