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Taking chance out of drug discovery
Author(s) -
Simon H. S. Pearce
Publication year - 2009
Publication title -
the biochemist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 7
eISSN - 1740-1194
pISSN - 0954-982X
DOI - 10.1042/bio03106040
Subject(s) - haystack , drug discovery , combinatorial chemistry , computer science , drug development , drug , nanotechnology , process (computing) , biochemical engineering , data science , computational biology , chemistry , engineering , bioinformatics , materials science , world wide web , biology , pharmacology , operating system
Searching for bioactive molecules, using rapid compound screening, fragment-based design and unique building blocks, should not be like looking for a needle in a haystack. This article describes a range of innovative and diverse screening compounds for drug discovery and development. Available at both research and development scales, the line includes special products associated with new heterocyclic and phenyl ring-based chemical building blocks, including an exclusive and expanding range of reactive intermediates specifically designed for lead optimization, as well as a growing fragment collection. I explain how these products and services are helping to accelerate the search for bioactive molecules and are shortening the drug discovery process by reducing the element of chance.

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