Oestrogen receptors: An intriguing double act | Zendy

Rodrigo P. A. Barros | Zendy; Jan-Ακε Gustafsson | Zendy

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Oestrogen receptors: An intriguing double act

Author(s) -

Rodrigo P. A. Barros,

Jan-Ακε Gustafsson

Publication year - 2009

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio03102008

Subject(s) - receptor , oestrogen receptor , tritium , nuclear receptor , medicine , endocrinology , microbiology and biotechnology , biology , chemistry , biochemistry , cancer , physics , breast cancer , nuclear physics , transcription factor , gene

The birth of nuclear receptors took place at the end of the 1950s when Elwood Jensen discovered specific binding of tritium-labelled oestradiol-17 in the uterus, a known target of oestrogens. Over the following years, Jensen and collaborators, e.g. Jacobsen and Gorski, identified the oestradiolconcentrating mechanism as a high-affinity low-capacity soluble receptor which was termed the ER (oestrogen receptor)1.

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