Defeating dementia: Current approaches to potential amyloid-based Alzheimer's disease therapies | Zendy

Ayesha Khan | Zendy; Clive Ballard | Zendy

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Defeating dementia: Current approaches to potential amyloid-based Alzheimer's disease therapies

Author(s) -

Ayesha Khan,

Clive Ballard

Publication year - 2008

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio03005014

Subject(s) - disease , dementia , cholinesterase , medicine , neuroscience , amyloid (mycology) , amyloid β , alzheimer's disease , psychology , pharmacology , pathology

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, accounting for 7 people in the UK and 25 million people worldwide with dementia1. Already licensed treatments, cholinesterase inhibitors and an NMDA (Nmethyldaspartate) receptor antagonist, confer important symptomatic benefits2, but at present, there are no treatments that can delay or halt the disease progression. This review outlines one of the main mechanisms currently thought to underpin the development of AD, and the treatments that are being developed based upon it.

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