Open AccessSilencing rogue gense: RNA-targeted therapies
Author(s) -
Matthew J. A. Wood
Publication year - 2008
Publication title -
the biochemist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 7
eISSN - 1740-1194
pISSN - 0954-982X
DOI - 10.1042/bio03003014
Subject(s) - rna , oligonucleotide , nucleic acid , computational biology , gene silencing , small interfering rna , trans acting sirna , biology , rna silencing , rna interference , gene , genetics
Advances in RNA biology have led to the development of nucleic acid therapeutic agents targeting RNA. Such agents are small oligonucleotides of diverse structures and chemistries that resemble standard pharmacotherapeutics more than conventional gene therapies, with the ability to yield a range of therapeutic transformations on different types of target RNA.
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