Chains of command: Ubiquitin in proinflammatory signalling | Zendy

Karine Enesa and Paul C. Evans | Zendy

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Chains of command: Ubiquitin in proinflammatory signalling

Author(s) -

Karine Enesa and Paul C. Evans

Publication year - 2007

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio02904024

Subject(s) - ubiquitin , proinflammatory cytokine , signalling pathways , signalling , microbiology and biotechnology , inflammation , signal transduction , chemistry , biology , immunology , biochemistry , gene

The 2004 Nobel Prize in Chemistry was awarded to Aaron Chiechanover, Avram Hershko and Irwin Rose for their pioneering studies of ubiquitination and its role in regulating protein stability. Now, 30 years after their discovery, we are beginning to understand the pleiotropic nature of ubiquitin and its roles in diverse physiological processes. Here we review an emerging concept that the signal ling pathways that control inflammation are tightly regulated by a multitude of ubiquitination and deubiquitination reactions.

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