Open AccessGetting hooked: Morphine tolerance
Author(s) -
Christopher Bailey
Publication year - 2007
Publication title -
the biochemist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 7
eISSN - 1740-1194
pISSN - 0954-982X
DOI - 10.1042/bio02902012
Subject(s) - desensitization (medicine) , morphine , opioid , μ opioid receptor , drug tolerance , pharmacology , neuroscience , receptor , chemistry , biology , biochemistry
Morphine acts on the Gi/Go-coupled -opioid receptor (MOR). The cellular mechanisms underlying tolerance to morphine are poorly understood but research has focused on desensitization and trafficking of MORs. Surprisingly, different agonists at the MOR elicit desensitization by entirely different cellular mechanisms.
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