Gripping stuff: Allosteric ribozymes | Zendy

Andrea Rentmeister | Zendy; Michael Famulok | Zendy

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Gripping stuff: Allosteric ribozymes

Author(s) -

Andrea Rentmeister,

Michael Famulok

Publication year - 2006

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio02802017

Subject(s) - ribozyme , allosteric regulation , aptamer , rational design , oligonucleotide , computational biology , ligand (biochemistry) , small molecule , chemistry , molecular recognition , effector , computer science , combinatorial chemistry , nanotechnology , molecule , rna , biology , biochemistry , enzyme , receptor , dna , materials science , genetics , gene , organic chemistry

Allosteric ribozymes combine the features of ligand-binding aptamers with the catalytic activity of ribozymes and can be generated by rational design or diverse selection strategies. Their activity can be controlled by different types of effectors, ranging from small molecules to oligonucleotides and proteins. This direct coupling of molecular recognition to signal generation in real time allows the generation of versatile reporters that can be applied to report molecular interactions.

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