Promiscuity in the Archaea: The enzymology of their metabolic pathways | Zendy

Michael J. Danson | Zendy; David W. Hough | Zendy

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Promiscuity in the Archaea: The enzymology of their metabolic pathways

Author(s) -

Michael J. Danson,

David W. Hough

Publication year - 2005

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio02701017

Subject(s) - archaea , metabolic pathway , enzyme , promiscuity , anabolism , catabolism , biology , biochemistry , ecology , gene

The pathways of central metabolism provide the metabolic connections between the catabolic (degradative) and anabolic (biosynthetic) routes in all living organisms. In hyperthermophilic Archaea, we have discovered a promiscuous central metabolic pathway that catabolizes a variety of sugars using a single set of enzymes. This article explores the structural basis of this promiscuity in enzymes that have to maintain their integrity at temperatures approaching 100°C.

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