Death without stress: The stiletto approach against disease | Zendy

Jo Milner | Zendy

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Death without stress: The stiletto approach against disease

Author(s) -

Jo Milner

Publication year - 2004

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio02605016

Subject(s) - rna interference , gene silencing , gene , biology , programmed cell death , rna silencing , disease , genetics , rna , medicine , apoptosis , pathology

Gene silencing by RNA interference (RNAi) allows, for the first time, investigation of the balance between the life and death of a cell under stress-free conditions. Thus it is now possible to (i) identify key antiapoptotic genes that constitutively enable, for example, cancer cell survival, and (ii) map the pathways such genes control (using RNAi co-silencing). New gene targets for anticancer therapy are identified and, full circle, RNAi provides the means for their selective therapeutic silencing.

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