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Getting the whole story: The role of high-content analysis
Author(s) -
Paul Wylie,
Wayne H. Bowen
Publication year - 2004
Publication title -
the biochemist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 7
eISSN - 1740-1194
pISSN - 0954-982X
DOI - 10.1042/bio02602027
Subject(s) - g protein coupled receptor , high content screening , computational biology , kinase , receptor , population , computer science , data science , biology , microbiology and biotechnology , medicine , biochemistry , cell , environmental health
High-content screening (HCS) is the measurement of complex cellular responses in a population of whole cells in parallel. It provides additional knowledge that can be critical when determining which targets to investigate and which lead compounds to pursue. In this article, we highlight the advantages of HCS analysis over traditional biochemical assays, using work on G-protein-coupled receptors (GPCRs) and kinases as examples.

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