The ancient battle for iron: Our struggle with pathogens | Zendy

Andrew M. Prentice | Zendy; Conor Doherty | Zendy; Joann M. McDermid | Zendy; Sarah Atkinson | Zendy; Sharon E. Cox | Zendy

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The ancient battle for iron: Our struggle with pathogens

Author(s) -

Andrew M. Prentice,

Conor Doherty,

Joann M. McDermid,

Sarah Atkinson,

Sharon E. Cox

Publication year - 2003

Publication title -

the biochemist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.126

H-Index - 7

eISSN - 1740-1194

pISSN - 0954-982X

DOI - 10.1042/bio02506015

Subject(s) - malaria , battle , vaccination , natural selection , wet season , plasmodium falciparum , new guinea , immunology , medicine , biology , environmental health , history , ethnology , ecology , ancient history , population

Young children in rural Gambia face constant exposure to gastrointestinal and respiratory infections and, during the rainy season (July–November), suffer recurrent bouts of Plasmodium falciparum malaria. Within living memory, these conditions led to more than half of the children dying before their fifth birthday, providing a graphic demonstration of the impact that infectious diseases have had on our natural selection. Fortunately, these horrific statistics have been decreased greatly by improved medical care, especially through vaccination and anti-malarial therapies, but conditions such as these have inevitably left a powerful imprint on man's genetic make-up.

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